This is a 60-minute MOC Section 3-accredited webinar for Canadian HCPs involved in the care of patients with advanced melanoma. While long-term clinical trial follow-up and emerging evidence continue to shape first-line treatment decisions, treatment selection remains complex in the absence of head-to-head randomized comparisons. This webinar is designed to provide evidence-based insights to help clinicians interpret long-term efficacy and safety data, integrate evolving evidence into individualized treatment decisions, and balance durable clinical outcomes with treatment burden and patient preferences. Through expert discussion and case-based scenarios, participants will gain practical strategies to support first-line treatment decision-making for patients with unresectable and/or metastatic cutaneous melanoma.